Understanding Platelet-Rich Plasma as Potential Therapy To Improve Cardiac Function After Myocardial Infarction: Based On Evidence

Myocardial infarction is the leading cause of death in world’s population. The sudden and progressive loss cardiomyocyte contractile cells due to disproportionate number new formation. This pathological condition will ultimately reduce function heart muscles. Platelet-rich plasma (PRP) last decade has been attracting attention regarding its role cell regeneration. content cytokines growth factors contained PRP such as Platelet-Derived Growth Factor (PDGF), Transforming Beta 1 (TGF-Β1), Epidermal (EGF), Vascular Endothelial (VEGF), Basic Fibroblast (bFGF) others are known be involved migration, proliferation, differentiation various types induce post-ischemic angiogenesis. review aims analyze investigate benefits therapy myocardial infarction. Recent literatures use was collected by searching PubMed Google Scholar databases with keywords “Platelet-rich plasma”, “Myocardial Infarction”, “Reperfusion”, “Angiogenesis”. researches used published between January 2011 December 2022. Based on results, Plasma considered capable accelerating angiogenesis, mitogenesis, protect from free radicals, infarct area scar tissue can also improve cardiac post increasing ejection fraction. In addition, treatment costs risk complications bleeding infection.